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General frequently asked questions

Welcome to the FAQ page for COMPASS, an advancing computational pipeline designed to analyze disease-associated coding variants and their impact on protein structure and function. This page addresses common questions about our approach, its applications in drug discovery, and how to access our resources. Explore the questions below to learn more about how COMPASS is advancing precision medicine.

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By identifying critical protein regions affected by variants, COMPASS pinpoints potential therapeutic targets. Its ability to link genetic variants to structural changes supports the development of targeted therapies.

Yes, COMPASS is designed to analyze both common and rare coding variants. Its flexible pipeline, combining genomic data analysis and AI-predicted protein structures, effectively evaluates their functional and structural impacts across diverse disease contexts.

COMPASS focuses on disease-associated coding variants and provides a comprehensive pipeline that maps variants to transcript-specific amino acid changes, localizes their impacts on protein structures, and evaluates the resulting functional implications. By integrating AI-predicted protein structures and large language models like ChatGPT and DeepSeek, it provides insights into disease mechanisms and structure-based drug design.